Endokrynologia Polska 2011, tom 62 nr 3

Nadchodzi czas długo wyczekiwanych letnich wakacji.  Jak co roku staramy się, aby w czasie słonecznej  kanikuły nie zabrakło nikomu możliwości sięgnięcia po  kolejny zeszyt Endokrynologii Polskiej.  Dział Prac oryginalnych rozpoczynamy doniesieniem pochodzącym z ośrodka krakowskiego...

Radioiodine treatment of hyperthyroidism in Graves’ disease patients may cause or aggravate the course of ophthalmopathy  (GO). We evaluated the activity and severity of ophthalmopathy in patients who acquired GO following radioiodine therapy...

The aim of this study was to investigate the effect of the decreased level of thyroid hormones on selected parameters of the  oxidation/reduction balance by assessing the activity of antioxidant enzymes: superoxide dismutase (SOD), and glutathione peroxidase  (GSH-Px); the level of antioxidant vitamins (A, C, and E); and the concentration of compounds reacting with thiobarbituric acid (TBARS)...

Kallmann syndrome type 1 (KS1) is a heterogeneous disorder where hypogonadotropic hypogonadism (HH) associated with  an impaired sense of smell is observed. The aim of this study was to investigate the usefulness of the multiplex ligation-dependent probe  amplification (MLPA) technique for differential diagnosis in comparison with molecular cytogenetics — fluorescence in situ hybridisation  (FISH) or traditional PCR analysis and propose a diagnostic approach for patients with KS...

Non-standard hypertrophy of the adrenal cortex is a rare endocrinopathy causing the incidence of  hyperandrogenism among women of procreative age.  The primary objective of this paper is the specification of the clinical picture and modifications of the concentration of pituitary, ovarian  and adrenal hormones in the blood of female patients with the syndrome of non-standard hypertrophy of the adrenal cortex (NPKN)...

The increased incidence of cardiovascular disease in women with polycystic ovary syndrome (PCOS) has prompted  researchers  to look for indicators of early atherosclerotic changes in these patients. One of the earliest stages of atherogenesis is endothelial  cell dysfunction...

Vitamin D deficiency is high in winter because of reduced exposure to sunlight. It seems that in places with high humidity and a sultry climate, exposure to sunlight in summer can be low too. This study was designed to determine the vitamin D deficiency prevalence in Sari, a city with a high humidity climate at the end of summer, and compare it to winter...

This study aimed to examine the effects of melatonin supplementation on liver glycogen levels in rats with streptozotocin- induced diabetes and subjected to acute swimming exercise...

The hormone leptin is secreted from white adipocytes, and serum levels of leptin correlate with adipose tissue mass. Leptin was first  described as acting on the satiety centre in the hypothalamus through specific receptors (ob-R) to restrict food intake and enhance energy  expenditure...

Hypogonadotropic hypogonadism (HH) is characterised by delayed puberty and infertility. Congenital HH comprises Kallmann syndrome  with hypo-/anosmia and idiopathic HH (IHH). The genetic origin remains unknown in most cases, but the defective GnRH receptor gene   (GNRHR) accounts for a considerable proportion of IHH.  Here we describe a pair of siblings diagnosed with IHH. Aged 17 years, the boy was referred because of short stature (162 cm) and overweight  (62.5 kg)...