Tag: Cushing’s disease

Adrenocorticotropic hormone (ACTH) — secreting pituitary adenoma consisting of corticotropic cells is the most frequent cause of endogenous hypercortisolaemia. Its presence can lead to complications, such as hypertension, impaired glucose tolerance, diabetes, osteoporosis, increased incidence of infections, or depression...

Without treatment, Cushing’s disease has significant morbidity and mortality. Where a surgical approach may not be feasible, or is refused by the patient, medical therapy becomes the only option. In this case report, we discuss the effects of two years of ketoconazole treatment on diabetes regulation and insulin resistance in a patient reluctant to agree to surgery. A 62 year-old female patient with uncontrolled type 2 diabetes mellitus was investigated...

Cushing’s disease is the commonest cause of endogenous hypercortisolaemia. In the majority of cases, it is caused by a pituitary, corticotroph adenoma autonomously producing ACTH [1–4]. Corticotrophin affects the adrenal cortex leading to cortisol excess.

Cushing’s disease (CD) is the commonest cause of endogenous hypercortisolemia. The disease incidence is estimated at 1–3 cases per 1 million people per year with its peak observed in the 3rd–5th decades of life. The disease affects women 4–8 times more often than men. In the under-10year-old age group, Cushing’s disease is diagnosed sporadically and is the least common cause of hypercortisolemia. After puberty, an increase in the incidence rate is observed [1–4].

Cushing’s disease is a rare endocrine disorder, with an incidence of 1–2 cases per million population per year. It results from adrenocorticotrophin (ACTH)-producing pituitary adenomas with a consequential overproduction of cortisol. It accounts for around 80–85% of patients with ACTH-dependent Cushing’s syndrome (CS) and in adults three out of four cases affect women, although in pre-pubertal children it is more common in males [1].