Tag: electrocardiogram

In the period 1890 to 1895, Willem Einthoven greatly improved the quality of tracings that could be directly obtained with the capillary electrometer. He then introduced an ingenious correction for the poor frequency response of these instruments, using differential equations...

Plasma cardiac troponins (cTn) are frequently elevated in acute pulmonary embolism (APE). ST-segment abnormalities on electrocardiography are also commonly observed in APE patients. However, it has not been defined which ventricle is a potential source of cTn release...

Two patients with acute myocardial infarction were admitted with unremarkable electrocardiograms, which did not revealthe location of the damage. A review of these electrocardiograms led to a suspicion of the presence of Brugada sign (BRSG),something subsequently confirmed by the administration of a sodium channel blocker...

Historically, the heart rate corrected QT (QTc) interval has been the standard method to assess for impaired ventricular repolarization, particularly for drug development. However, QTc does not reflect changes in autonomic state or QT-RR hysteresis which can also affect the interpretation of arrhythmogenic risk...

We implemented an ECG data-warehousing project to promote cross-fertilization of scientific knowledge, resources and ideas that will advance the understanding of quantitative ECG and cardiac safety. While other open ECG databases are available, our Telemetric and Holter ECG Warehouse (THEW) proposes unique sets of continuous digital ECGs recorded in cardiac patients, healthy individuals and individuals exposed to non-cardiac and cardiac drugs....

We implemented an ECG data-warehousing project to promote cross-fertilization of scientific knowledge, resources and ideas that will advance the understanding of quantitative ECG and cardiac safety...

Several studies have reported that primary hyperparathyroidism is a risk factor of higher cardiovascular mortality, mainly because hyperparathyroidism is related to arterial hypertension, arrhythmias, structural heart abnormalities and activation of the renin–angiotensin– aldosterone system. However, very few studies have shown the electrocardiographic changes that occur after parathyroidectomy...

Intravenous adenosine in conjunction with myocardial perfusion imaging is commonly used for the detection of coronary artery disease and risk assessment. We have previously shown that patients with ischemic changes on the 12-lead electrocardiogram (ECG) in response to adenosine but with normal perfusion pattern have a benign outcome on shortintermediate follow-up. The long-term outcome of these patients is unknown...

Inferior acute myocardial infarction (AMI) represents 40–50% of all AMIs. The culprit lesion is almost exclusively either in the right coronary artery (RCA) or the left circumflex coronary artery (LCx). Without doubt, the electrocardiogram (ECG) plays a crucial role in identifying the infarct-related artery because it is cheap and universally available...

Accurate and precise QT interval measurement is very important for both regulatory and drug developmental decision making. These measurements are often made using a manual or semi-automated technique, and the associated variability necessitates sample sizes of around 50 to 70 subjects in thorough QT/QTc studies...