Tag: ghrelin

Ghrelin is a 28-aminoacid peptide secreted mainly by the stomach cells [1]. The highest plasma ghrelin concentration is usually detected in the fasting state [2, 3]. The decrease of plasma ghrelin concentration observed after feeding is not related to gastric distension but rather to the stimulation of the cholinergic nervous system via the vagus nerve, glucose absorption, and probably insulin release [4–7]...

Recently published studies have revealed the increased prevalence of depression in obese subjects [1–3]. However, it is unknown whether depression leads to obesity or obesity is a causative factor for the development of depression. Numerous links between obesity and depression have been proposed, such as disturbances in serotonin release [4], increased activity of the hypothalamic- pituitary-adrenal (HPA) axis and sympathetic nervous system [5, 6], and disturbed release of epinephrine,dopamine, and NPY [7–11]...

Resistance to insulin is defined as an impaired biological response to both endogenous and exogenous insulin. In other words, it is a disorder of insufficient insulin efficacy to tissues such as liver, skeletal muscle, and adipose [1]. Although the pathophysiology of peripheral resistance to the action of insulin has not been fully characterized in male hypogonadism, measurable knowledge has been reported in several studies...

Otyłość stanowi ważny problem medyczny. Obserwowany jest stały wzrost częstości jej występowania. Przyczyną otyłości w głównej  mierze jest zwiększona podaż energii...

In animal models ghrelin reduces cardiac afterload and increases cardiac output via receptors in the cardiovascular system.The aim of our study was to evaluate a potential relationship between weight loss treatment, blood pressure and serum ghrelin concentration  in obese women...

The aim of the present study was to examine how weight loss treatment modulates plasma concentrations of ghrelin and insulin-like growth factor 1 (IGF-1) in obese women and to determine whether there is any association with possible changes in plasma concentrations of these hormones after weight loss...

Diet, exercise, and pharmacological therapy have been shown to be unsatisfactory treatments for severe obesity in the long  term. Bariatric surgery is the most effective means to achieve weight loss in morbidly obese subjects.  The aim of this study was to evaluate the action of a number of adipocytokines, as well as the metabolic syndrome   parameters of obese  patients, before and after vertical banded gastroplasty (VBG)...

In recent years we have performed more than 1,000 radioimmunoassays of ghrelin and obestatin. In these assays, we have encountered several technological obstacles. Another difficulty was the enormous discrepancy of plasma ghrelin results published by different authors.

Cannabinoids participate in the modulation of numerous functions in the human organism, increasing the sense of hunger, affecting carbohydrate and lipid metabolism, and controlling systemic energy balance mechanisms...

Ghrelin and obestatin are two peptides deriving from the same precursor — preproghrelin [1–3]. Due to their common origin, both peptides are of particular interest regarding their compatible or opposite biological functions.