Tag: immunohistochemistry

Ovarian cancer, being the sixth most frequently occurring cancer in the world, takes the second place(after cervical cancer) with respect to the occurrence of reproductive organ cancers, and is the fifth mostcommon cause of death due to cancer in women. Annually over 3000 new cases are noted in Poland(reports based on data from the National Cancer Registry, Poland)...

Plurihormonality of pituitary adenomas can be defined as the ability of an adenoma to express more than one pituitary hormone. According to the recommendations of the WHO, the gonadotropinomas expressing both gonadotropins, i.e. FSH and LH, are not considered plurihormonal. The same concerns adenomas in patients with acromegaly, secreting prolactin in addition to GH [1]. Plurihormonal adenomas leading to the elevated concentrations of more than one pituitary hormone in blood are considered relatively rare...

The highly variable expression of SSTR subtypes in pituitary adenomas (PA) may partially explain why the subgroup ofsomatotropinomas or other adenomas do not respond to the therapeutic action of currently used long-acting somatostatin analogues like  octreotide or lanreotide....

Rak płuca to najczęściej występujący na świecie nowotwór złośliwy. Rokowanie w raku płuca pozostaje niekorzystne. Zgodnie z danymi epidemiologicznymi 5-letnie przeżycie uzyskuje się zaledwie u 10–15% pacjentów [1]...

Evidence collected over the years has demonstrated that cryptorchidism is associated with a defect in spermatogenesis and,  as a consequence, with either reduced fertility or infertility. However, the effect of cryptorchidism on Leydig cell function is less clear...

Thyroid hemiagenesis (TH) is characterized by the congenital absence of one thyroid lobe. The aim of this study was to evaluate the calcium-phosphate balance in TH. Twenty patients with TH and 20 controls with a bilobed thyroid were studied. Serum concentrations of total calcium, parathormon and calcitonin were measured. Additionally, the immunohistochemical expression of calcitonin, chromogranin A (chA), neuron-specific enolase (NSE) and calcitonin gene-related peptide (CGRP) was evaluated in surgical specimens from patients with TH and controls...

The aim of our study was to elucidate the possible involvement of COX-2 in the development and/or progression of nonmelanocytic skin lesions. To evaluate the usefulness of that enzyme as a potential molecular marker, we examined the intensity and spatial distribution of COX-2 expression in selected types of such tumors using the same immunohistochemical procedure as in our earlier studies of melanocytic cancers...

Pattern recognition receptors (PRRs) constitute a pivotal arm of innate immunity. Their distribution is widespread and not limited to cells of the immune system. Following our previous findings concerning the expression of Toll-like receptors (TLRs) 2, 3 and 4 in chronic viral hepatitis C of children, we wished to search for other PRRs, including other TLRs, NOD-like receptors (NLRs) and RIG-1-like helicase receptors (RLR) in infected hepatocytes...

We describe the presence of c-kit positive interstitial cells of Cajal-like (ICCs-like) in the walls of the urinary bladders of children. An immunohistochemical study of specimens, obtained at autopsy from either the trigonum (Group A) or the corpus (Group B), was performed using antibodies against c-kit (CD 117). Histological morphometry of the immunoexpression of c-kit positive ICCs-like was performed by means of image analysis system...

Mammalian aquaporins (AQPs) are a family of at least 13 integral membrane proteins expressed in various epithelia, where they function as channels to permeate water and small solutes. AQP5 is widely expressed in the exocrine gland where it is likely involved in providing an appropriate amount of fluid to be secreted with granular contents...