Tag: immunohistochemistry

Recently, dopamine D2 receptors (RD2) have been found to be expressed in neuroendocrine tumours (NET), the tumourswhich arise from the diffuse neuroendocrine cells. Moreover, successful trials of the treatment of NET with cabergoline — D2 agonist,have been reported. These findings increase the interest of investigating RD2 expression in NET....

The development of small molecule inhibitors of growth factor receptors, and the discovery of somatic mutations of the thyrosine kinase domain, have resulted in new paradigms for cancer therapy. Digital microscopy is an important tool for surgical pathologists. The achievements in the digital pathology field have modified the workflow of pathomorphology labs, enhanced the pathologist’s role in diagnostics, and increased their contribution to personalized targeted medicine...

The aim of the present study was to evaluate the expressions

and biological functions of the TGF-beta1/Smad signalling pathway of aortic disorders

by way of histopathological and immunohistochemical studies.

The detailed description of the distribution of endocrine cells G and D producing

important hormones that regulate activation of other cells in the human stomach

may be a valuable source of information for opinions about mucosa changes in

different diseases of the alimentary tract. The density and distribution of immunoreactive

G and D cells in the pylorus of humans (donors of organs) were evaluated.

The aim of the present study was to evaluate the morphology and intermediate filaments cytokeratin, desmin and vimentin expression in the kidneys of the polar fox (Alopex lagopus)...

The aim of this study was to investigate the role of apoptotic markers on inflammatory human placentas from spontaneous abortions during the first and second trimester of gestation and compare them to those without inflammation...

Caveolin-1 is the major protein component of caveolae that are cholesterol- and sphingolipid-enriched microdomains of the plasma membrane [1]. Because caveolae are believed to be involved in two-way communication and exchange of molecules between the cell and extracellular environment, caveolin-1 has been implicated in multiple cellular functions including endocytosis, signal transduction and cholesterol transport [2].

Galanin is a 29–30 amino acid neuropeptide, which is present in the central nervous system (CNS) and peripheral tissues. Its primary structure is highly conserved among vertebrates (almost 90%), indicating the importance of the neuropeptide.

Late prostate cancer (PC) recognition is the main cause of treatment failure, similarly as in other neoplastic diseases. Earlier recognition based on biological markers could be helpful in identification of biological differences in benign and malignant lesions, what could further help in precise indication for more aggressive post-operative treatment (chemo/radiotherapy).

Uterine myomas are the most common benign tumors in women, but in spite of this, the mechanisms and factors that control their formation and development are poorly understood. Many studies showed the participation of pro-inflammatory factors in the pathogenesis of various types of cancer [1–4] through their effects on cell growth and differentiation, apoptosis, angiogenesis, and tissue remodeling [1, 2, 4, 5], i.e. events that are central to tumor growth.