Tag: inflammation

Mononuclear phagocytes represent a heterogeneous population of cells with individual subpopulations exerting different pro- or anti-inflammatory functions. CD163 is a monocyte/macrophage specific marker expressed predominantly on cells which possess strong anti-inflammatory potential. The expression of CD163 is strongly induced by anti-inflammatory mediators such as glucocorticoids and interleukin-10, while being inhibited by pro-inflammatory mediators such as interferon-gamma. CD163-expressing mononuclear phagocytes, as well as soluble CD163, may both take part in downregulating an inflammatory response....

Mimo agresywnej farmakoterapii niewydolność serca pozostaje ważnym problemem klinicznym. Dostępne leki jedynie łagodzą symptomy i zwalniają postęp choroby, ale rokowanie pacjentów pozostaje niekorzystne...

Patogeneza pierwotnego nadciśnienia tętniczego jest złożona i nie do końca poznana. Coraz więcej faktów doświadczalnych i klinicznych wskazuje na istotną rolę przewlekłego zapalenia w patogenezie tego schorzenia.

Background: Before introduction of reperfusion therapy, fever was frequently observed in patients with acute myocardial infarction (AMI). Little is known about this symptom during the widespread use of primary percutaneous coronary intervention (pPCI). The aim of this study was to assess, whether body temperature is a predictor of impaired left ventricular systolic function in patients with AMI...

Background: QRS complex fragmentations can frequently be seen on routine ECG with narrow or wide QRS complex. Fragmented QRS complexes (fQRS) are defined as various RSR' patterns (≥ 1 R' or notching of S wave or R wave) in two contiguous leads corresponding to a major coronary artery territory. In previous studies, fQRS has been associated with increased morbidity and mortality, sudden cardiac death and recurrent cardiovascular events. The causative relationship between fQRS and cardiac fibrosis has been shown, but it has not been extensively studied whether there are different mechanisms for the development of fQRS...

Patients with type 2 diabetes (T2DM) have a 2- to 4-fold higher risk for cardiovascular (CV) disease as compared with non-diabetic individuals [1]. It is caused partly by hypercoagulable state as evidenced by high platelet reactivity (HPR) [2]. Etiology of HPR is complex, and seems to be a result of hyperglycemia, metabolic disorders, oxidative stress and inflammation [3]...