Tag: insulin resistance

A bilayer lipid cell membrane is impermeable to monosaccharides, and therefore glucose needs a biological transport system consisting of specialized transport proteins. Those proteins provide physiological harmony of glucose cell supply and its further metabolism...

Insulin regulatory action involves the basic life processes of cells, tissues, and whole organisms. It is multifactorial, perfectly organized, and functionally integrated into successive biochemical steps and biological events governing intracellular regulation. The primary signal resulting from the association of the insulin molecule with the alfa subunit of its specific receptor is transducted by the whole system of mediating molecules and transcriptional factors to over 100 genes [1–3]...

Resistance to insulin is defined as an impaired biological response to both endogenous and exogenous insulin. In other words, it is a disorder of insufficient insulin efficacy to tissues such as liver, skeletal muscle, and adipose [1]. Although the pathophysiology of peripheral resistance to the action of insulin has not been fully characterized in male hypogonadism, measurable knowledge has been reported in several studies...

Insulin regulatory action involves the basic life processes of cells, tissues, and whole organisms. It is multifactorial, perfectly organized, and functionally integrated into successive biochemical steps and biological events governing intracellular regulation. The primary signal resulting from the association of the insulin molecule with the alfa subunit of its specific receptor is transducted by the whole system of mediating molecules and transcriptional factors to over 100 genes [1–3]...

Adipose tissue is a highly active metabolic and endocrine organ secreting a range of bioactive peptides with both local and distant actions [1–3]. Some of these factors, known as ‘adipokines’ or ‘adipose tissue hormones’, are specific fat-related hormones that are involvedin regulating energy homeostasis, carbohydrate and lipid metabolism, and the function of the cardiovascular system [1-3]...

Homozygosity for interleukin-6 (IL-6) 174G_C promoter polymorphism has recently been associated with indices of metabolicsyndrome; however, this problem has not been investigated in non-obese subjects...

Acromegaly is characterized not only by disabling symptoms, but also by relevant co-morbidities. Insulin resistance, leadingto glucose intolerance is one of the most important contributory factors to the cardiovascular mortality in acromegaly...

The aim of the study was the selection of patients with confirmed severe GHD from among all the children treated due to GHD, who could benefit from GH therapy continuation in adulthood and the optimization of GH dosage in young adults with severe GHD...

Secretory products from adipocytes may contribute to deterioration in glycaemic control and increased insulin resistance (IR). Retinol-binding protein 4 (RBP-4) may increase IR in mice, with elevated levels in insulin-resistant mice and humans with obesity and type 2 diabetes. However, the mechanisms regulating RBP-4 synthesis remain not fully understood...

Przedstawione przez autorów niniejszej pracy obserwacje wykazały, że u młodzieży z różnymi postaciami zaburzenia tolerancji glukozy w celu poprawy metabolizmu glukozy można zastosować doustne leki przeciwcukrzycowe. Metforminę szeroko stosuje się u pacjentów  pediatrycznych i uważa się ją za najbardziej efektywny lek doustny...