Tag: insulinooporność

A bilayer lipid cell membrane is impermeable to monosaccharides, and therefore glucose needs a biological transport system consisting of specialized transport proteins. Those proteins provide physiological harmony of glucose cell supply and its further metabolism...

Insulin regulatory action involves the basic life processes of cells, tissues, and whole organisms. It is multifactorial, perfectly organized, and functionally integrated into successive biochemical steps and biological events governing intracellular regulation. The primary signal resulting from the association of the insulin molecule with the alfa subunit of its specific receptor is transducted by the whole system of mediating molecules and transcriptional factors to over 100 genes [1–3]...

Resistance to insulin is defined as an impaired biological response to both endogenous and exogenous insulin. In other words, it is a disorder of insufficient insulin efficacy to tissues such as liver, skeletal muscle, and adipose [1]. Although the pathophysiology of peripheral resistance to the action of insulin has not been fully characterized in male hypogonadism, measurable knowledge has been reported in several studies...

Insulin regulatory action involves the basic life processes of cells, tissues, and whole organisms. It is multifactorial, perfectly organized, and functionally integrated into successive biochemical steps and biological events governing intracellular regulation. The primary signal resulting from the association of the insulin molecule with the alfa subunit of its specific receptor is transducted by the whole system of mediating molecules and transcriptional factors to over 100 genes [1–3]...

Adipose tissue is a highly active metabolic and endocrine organ secreting a range of bioactive peptides with both local and distant actions [1–3]. Some of these factors, known as ‘adipokines’ or ‘adipose tissue hormones’, are specific fat-related hormones that are involvedin regulating energy homeostasis, carbohydrate and lipid metabolism, and the function of the cardiovascular system [1-3]...

Homozygosity for interleukin-6 (IL-6) 174G_C promoter polymorphism has recently been associated with indices of metabolicsyndrome; however, this problem has not been investigated in non-obese subjects...

Acromegaly is characterized not only by disabling symptoms, but also by relevant co-morbidities. Insulin resistance, leadingto glucose intolerance is one of the most important contributory factors to the cardiovascular mortality in acromegaly...

Nadwaga i otyłość stały się w XXI wieku „plagą cywilizacyjną”, mającą istotny wpływna rozwój wielu przewlekłych chorób. W ostatnich latach wiele uwagi poświęca się udziałowi tkanki tłuszczowej jako źródła substancji aktywnych biologicznie, nazywanych adipokinami...

W świetle wyników badań doświadczalnych i klinicznych, przeprowadzonych w ostatnich latach, związek między układem nerwowym a metabolizmem węglowodanów należy rozpatrywać nie tylko w aspekcie powikłań stanów przedcukrzycowych, cukrzycy czy zespołu metabolicznego, ale również w kontekście neurogennych mechanizmów regulujących przemianę węglowodanów ...