Tag: ischemia

Coronary artery disease is a leading cause of death worldwide. The main pathological manifestation of coronary artery disease is myocardial damage due to ischemia-reperfusion injury [1]. Clinically, myocardial ischemia-reperfusion relates to conditionssuch as myocardial infarction, coronary angioplasty, thrombolytic therapy, coronary revascularization and heart transplantation [2]...

Ischemic-reperfusion injury (IRI) is defined as tissue damage, organ dysfunction or failure developed in the course of inflammatory response following ischemia and reperfusion (IR). Abdominal aortic aneurysm (AAA) repair required IR of distal parts of the body carries a risk of organ injury and postoperative mortality of between 4% and 12%...

The restoration of coronary flow is necessary to reduce ischemic myocardial damage due to acute vessel occlusion. However, during the reperfusion period, an additional damage of cardiac tissue occurs resulting in an ischemia/reperfusion (I/R) injury [1]. I/R injury causes a necrosis and apoptosis of cardiomyocytes and in clinical settings it may manifests as a myocardial stunning observed after the global ischemia during the cardiac surgery [2] or as an impaired coronary flow (no-flow phenomenon) [3] due to microvessels dysfunction observed after the percutaneous coronary angioplasty...