Tag: long QT syndrome

We implemented an ECG data-warehousing project to promote cross-fertilization of scientific knowledge, resources and ideas that will advance the understanding of quantitative ECG and cardiac safety. While other open ECG databases are available, our Telemetric and Holter ECG Warehouse (THEW) proposes unique sets of continuous digital ECGs recorded in cardiac patients, healthy individuals and individuals exposed to non-cardiac and cardiac drugs....

We implemented an ECG data-warehousing project to promote cross-fertilization of scientific knowledge, resources and ideas that will advance the understanding of quantitative ECG and cardiac safety...

Methadone is increasingly prescribed for chronic pain, yet the associated mortality appears to be rising disproportionately relative to other opioid analgesics. We review the available evidence on methadone-associated mortality, and explore potential pharmacokinetic and pharmacodynamic explanations for its greater apparent lethality...

Class III drugs prolong the QT interval by blocking mainly the delayed rectifier rapid potassium outward current (IKr), with little effect on depolarization. This K+ channel in encoded by the human ether-a-go-go-related gene (hERG). Inhibition of hERG potassium currents by class III antiarrhythmic drugs causes lengthening of cardiac action potential, which produces a beneficial antiarrhythmic effect. Excessive prolongation of the action potential may lead to acquired long QT syndrome, which is associated with a risk of “torsade de pointes”...

The KCNQ1 and HERG genes mutations are responsible for specific types of congenital long QT syndrome (LQT).  To examine the expression of KCNQ1 and HERG genes that encode potassium channels (rapid and slow) responsible  for the occurrence of particular types of LQT syndrome. The study also attempted to prove that beta-actin is a good endogenous  control when determining the expression of the studied genes...

Stress-induced cardiomyopathy is usually described as syndrome with good prognosis. Although the QT prolongation is usually associated with this cardiomyopathy, the life threatening arrhythmias are less frequent than expected. We present middle age woman with torsade de pointes caused by significant QTc interval prolongation on the basis of tako-tsubo cardiomyopathy, which could suggest not always mild course of this syndrome.