Tag: morphine

Despite a more than tenfold increase in opioid consumption in the past decades, many cancer patients still suffer pain. The current understanding of this situation is poorly understood. It is still possible that in some countries pain is still undertreated, but it is also possible that we do not appreciate opioid induced toxicity and other phenomena an/or our opioid prescribing needs to be refreshed...

It is well established that opioids help the organism to cope with environmental stress, tissue injury, pathogen invasion, inflammation, and tumor growth. Opioids elicit immunosupressive effects which may become benefitial in the context of chronic inflammation, however, it may be detremental in the context of tissue repair...

Understanding of the molecular mechanisms in the opioid systems in chronic pain should produce new, more effective methods of the pharmacotherapy of pain. Pharmacological suppression of glial activation in combination with morphine, methadone, fentanyl and buprenorphine may be an important aspect of pain therapy...

In an open, clinical study, preliminary assessment of analgesic efficacy and adverse effects of prolonged-release morphine sulphate capsules administered once-daily was conducted in patients with cancer whose pain required strong opioid analgesics administration...

We are all asked for consultations to see a complex patient or to answer the telephone call and think about the patient without seeing him and without touching him. Although this type of consultation is much cheaper, faster and sometimes effective. There is a danger that we hear only a part of the story, or a story coloured in such a way that it will push the decision in one direction, intended by a doctor or nurse who requested it...

The face of palliative care has changed considerably in the past four decades. The increased consumption of opioids did not fulfil the promise of freedom from pain.