Tag: multiple myeloma

Cytotoxicity of drugs can be a cause of cardiorespiratory disorders connected with chemotherapy.Doxorubicin is an antibiotic from the group of anthracyclines effective in antineoplastic therapy of solid and hematopoetic tumors. The most common cause of therapy ceasing is its cardiotoxicity...

We introduce a case of 45 year-old woman treated for multiple myeloma. In this patient acute coronary syndrome STEMIduring chemiotheraphy was occurred...

Multiple myeloma (MM) is a clonal B-lymphocyte neoplasm of terminally differentiated plasma cells. It accounts for approximately 1% of all malignant diseases and represents about 10% of haematologic malignancies. The annual incidence of newly diagnosed cases is approximately 3 to 4 per 100,000 population per year, with an estimated 14,000 new cases each year [1 ]. The cause of MM is unknown. Data from cloning and gene-sequencing studies strongly imply that the malignant clone in MM arises from a late cell in B-cell development [2, 3 ]...

Szpiczak mnogi jest klonalną proliferacją atypowych plazmocytów i chorobą nieuleczalną, mimo niewątpliwych postępów w leczeniu, jakie osiągnięto w ostatnich 10 latach. Coraz częściej wyboru terapii dokonuje się na podstawie zmian cytogenetycznych i molekularnych, które towarzyszą tej chorobie [1, 2]. Najczęściej występujące zmiany cytogenetyczne zestawiono w tabeli 1...

Patients with multiple myeloma (MM) treated with conventional chemotherapy have an average survival of approximately three years. High dose chemotherapy followed by autologous stem cell transplantation (ASCT), first introduced in the mid-1980s, is now considered the standard therapy for almost all patients with multiple myeloma, because it prolongs overall survival and disease free survival...

Mucins have been shown to be aberrantly overexpressed in various diseases including cystic fibrosis, asthma, and cancer. Recent studies have uncovered the roles of these mucins in the pathogenesis of cancer. The presence of MUC-1 has also been detected on the cell surface of multiple myeloma (MM) cells in peripheral blood and showed direct correlation with tumor mass...