Tag: platelet function testing
Lista treści zawierających tag platelet function testing:
Acetylsalicylic acid (ASA) inhibits platelet aggregation through irreversible acetylation of platelet cyclooxygenase (COX)-1 and subsequent inhibition of the transformation of arachidonic acid (AA) into thromboxane A2 (TxA2), a potent vasoconstrictor and aggregating agent [1]. ASA selectively and rapidly acetylates the COX-1 enzyme, and is, in this respect, 166 fold more effective in inhibiting COX-1 than COX-2 enzyme. In addition, immediate ASA-degradation product, salicylic acid (SA), weakly binds to a COX-1 second binding site at Arg120 and may contribute to ASA antiplatelet effect [2]...
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Opublikowano: 2013-10-22 16:12:40
Oryginalne wydanie: 2013-04-05
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