Tag: rak brodawkowaty tarczycy

Differentiated thyroid carcinomas (DTC) are usually characterized by a good prognosis and survival of patients [1–5]. Papillary thyroid carcinoma (PTC) represents 75–80% DTC, and 10-year survival is observed in 98% of patients. However, the disease may have anaggressive course and 5–27% of patients with DTC develop regional and/or distant metastases...

The prognostic impact and predictive value of clinical and histological features in differentiated thyroid cancers (DTC) [1–5], as well as an optimal treatment related to disease stage [3, 6–14], are still discussed. Recent molecular investigations constitute a new approach...

Papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), poorly differentiated (insular) thyroid carcinoma (PDTC), and undifferentiated (anaplastic) thyroid carcinoma are all non-medullary thyroid cancer histotypes (NMTC) which originate from thyroidepithelial cells [1]. Among them, 5% constitute hereditary cases (HNMTC)...

Human gene CHEK2 encodes CHK2 protein, a protein kinase engaged in DNA-repair. Activating cell substrates, it regulates the cell cycle and affects apoptosis and aging of cells [1, 2]. Mutations of the CHEK2 gene lead to the development of various cancers [1–3]. The two main groups of mutations of this gene are characterized by either truncation of the encoded protein or the missense type, with the substitution of one amino acid into another...

Współwystępowanie orbitopatii w przebiegu choroby Gravesa-Basedowa i raka zróżnicowanego tarczycy nie jest dobrze udokumentowane ze względu na rzadkość tej koincydencji...