Pulmonary hypertension in chronic obstructive pulmonary disease
Pulmonary hypertension (PH) is a common complication of advanced chronic obstructive pulmonary disease (COPD) and is definedby a mean pulmonary artery pressure (PAP) ≥ 25 mm Hg at rest in the supine position. Owing to its frequency, COPD is a commoncause of PH; in fact, it is the second most frequent cause of PH, just after left heart diseases. PH is due to the elevation of pulmonaryvascular resistance, which is caused by functional and morphological factors, chronic alveolar hypoxia being the most important.In COPD PH is generally mild to moderate, PAP usually ranging between 25 and 35 mm Hg in a stable state of the disease.A small proportion of COPD patients may present a severe or “disproportionate” PH with a resting PAP > 35–40 mm Hg. Theprognosis is particularly poor in these patients. In COPD PH worsens during exercise, sleep and severe exacerbations of thedisease, and these acute increases in afterload may favour the development of right heart failure.
Język: polski
Profil:
pneumonologia
Rodzaj: Artykuł, Dostęp: Dla wszystkich, Odpłatność: Darmowe