Baroreceptor sensitivity and diabetes mellitus

Autorzy: Olumide Olatubosun Rowaiye¹, Ewa Anita Jankowska², Beata Ponikowska¹ 1 - Department of Physiology, Wroclaw Medical University, Wroclaw, Poland
2 - Department of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland; Center for Heart Diseases, Military Hospital, Wroclaw, Poland

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Abstrakt

Diabetes mellitus (DM) is a disease of increasing incidence and prevalence. Arterial baroreceptors are stretch-sensitive receptors, which in a reflex manner are involved in the homeostatic control of arterial blood pressure. Diabetic subjects have depressed baroreflex sensitivity (BRS), although the exact pathomechanisms are unclear. In this review, we discuss the features, clinical and prognostic implications of reduced BRS for diabetic patients and the potential involvement of cardiovascular autonomic neuropathy and atherosclerosis. Finally, we demonstrate evidence on interventions (e.g. pioglitazone, alpha-lipoic acid, leptin, fluvastatin, physical training etc.) which could improve BRS and ameliorate cardiovascular autonomic dysfunction in diabetic patients.

Wydane przez: Via Medica
Data wydania: 2013-10-03
Język: angielski
Profil: choroby sercowo-naczyniowe

Tagi: diabetes mellitus, baroreflex sensitivity, cardiovascular autonomic neuropathy, autonomic dysfunction, arterial baroreceptors,

Rodzaj: Artykuł, Dostęp: Dla wszystkich, Odpłatność: Darmowe