Endokrynologia Polska 2011, tom 62, nr 2

W wiosennym nastroju, z optymizmem płynącym  z budzącego się na nowo życia — oddajemy Wam kolejny  numer „Endokrynologii Polskiej” (EP). Wydawać  by się mogło, że niewiele mamy do dopowiedzenia po  kolejnym udanym kursie kształcenia podyplomowego,  zorganizowanym przez Polskie Towarzystwo Endokrynologiczne  w malowniczej Ossie...

The aim of this study was to determine which factors increase the risk of metabolic syndrome (MS) and its components in  obese children and adolescents.  In 78 obese children (42 girls, 36 boys), mean age 14.6 ± 3.5 years, blood pressure, total cholesterol, triglycerides,  HDL-cholesterol (HDL), insulin and glucose at fasting state as well as in OGTT were measured. Body mass index (BMI) Z-score, LDLcholesterol,  and insulin resistance indices (FIGR, R-HOMA) were calculated...

Diet, exercise, and pharmacological therapy have been shown to be unsatisfactory treatments for severe obesity in the long  term. Bariatric surgery is the most effective means to achieve weight loss in morbidly obese subjects.  The aim of this study was to evaluate the action of a number of adipocytokines, as well as the metabolic syndrome   parameters of obese  patients, before and after vertical banded gastroplasty (VBG)...

Polycystic ovary syndrome (PCOS) is characterised by increased frequency of hypothalamic GnRH pulses leading to  a relative increase in LH synthesis by the pituitary. As GnRH stimulation can reveal a relative LH excess, we have endeavoured to assess  whether GnRH test might be useful in the diagnosis of PCOS...

A body of evidence points to a familial aggregation of hormonal abnormalities in first-degree relatives of women with  polycystic ovary syndrome (PCOS).  The aim of this study was to determine whether siblings of women with PCOS had evidence of hormonal abnormalities typical of PCOS...

While many studies support the theory that environmental factors play a role in the development of type 1 diabetes mellitus  (T1DM), controversy exists as to the contribution of any individual factor. The aim of the present study was therefore to investigate the  associations of T1DM with several environmental factors...

The aim of this study was to evaluate auditory organ function in relatively young type 1 diabetic patients, with short  duration of the disease and without overt hearing loss. The impact of age, diabetes duration and metabolic control on  hearing function was  also analysed...

The aim of this study was to investigate the roles of nutritional habits and addictions in the incidence of thyroid carcinoma.The study of risk factors affecting the incidence of thyroid carcinoma was conducted in patients included in a register  of thyroid carcinoma...

Angiotensin II (AngII), a peptide that regulates the water-electrolytic balance and blood pressure, is also known to influence cell  proliferation. It can either induce cell growth, when binding to angiotensin type-I receptor, or trigger growth inhibition via angiotensin  type-II receptor. AngII stimulates proliferation of some normal and tumour cell lines, e.g. pituitary, adrenal glands and breast cancer...

Alternative splicing of pre-mRNA is a process in which noncoding regions of primary transcript are removed and coding regions are  joined in different manners to produce mRNA molecules of different sequences. Alternative splicing affects nearly all human genes and is  a key source of diversity of proteins coded by a relatively small number of genes. Since alternative splicing is of crucial importance for the  proper functioning of cells, including those involved in hormonal signalling, aberrations of alternative splicing can lead to disruption of  cellular mechanisms and in consequence result in serious endocrine pathologies...