Endokrynologia Polska 2011, tom 62 nr 3

Primary pigmented nodular adrenocortical disease (PPNAD) is a rare adrenal tumour causing corticotrophin-independent Cushing’s syndrome. It occurs mainly in children and young adults. The histological examination is characterised by small pigmented micronodules on the adrenal cortex...

Without treatment, Cushing’s disease has significant morbidity and mortality. Where a surgical approach may not be feasible, or is refused by the patient, medical therapy becomes the only option. In this case report, we discuss the effects of two years of ketoconazole treatment on diabetes regulation and insulin resistance in a patient reluctant to agree to surgery. A 62 year-old female patient with uncontrolled type 2 diabetes mellitus was investigated...

Morning hyperglycaemia in diabetic subjects may be caused by the dawn phenomenon, or the Somogyi effect, or poor glycaemic control.  The dawn phenomenon occurs when endogenous insulin secretion decreases or when the effect of the exogenous insulin administered  to the patient the day before disappears, together with a physiological increase in insulin-antagonistic hormones...

We read with great interest the article by Karadurmus  et al. in which the effects of hyperbaric oxygen therapy  on glycaemic control, inflammation markers and atherosclerosis  were investigated in diabetic patients with foot  ulceration...