Endokrynologia Polska 2012, tom 63, nr 1

W Wasze ręce trafia pierwszy w tym roku numer „Endokrynologii Polskiej”. Jest to rok szczególny, zapowiadający wiele ciekawych naukowych wydarzeń endokrynologicznych — z najważniejszym, jakim jest XX Jubileuszowy Zjazd PTE w Poznaniu.

The differentiation of adrenal nodules is wide and varies from primary benign neoplasia, through hormone secreting lesions, to primary and secondary malignant masses.

Thyroid function disorders affect between 5% and 15% of patients treated with IFNa and RBV for chronic hepatitis C.

We present the diagnostic and therapeutic difficulties encountered in a patient with a clinically advanced pancreatic neuroendocrine tumour.

Coeliac disease is a gluten-sensitive enteropathy of varying severity. Osteomalacia and hypocalcaemia can result from malabsorption of vitamin D and calcium, which, in turn, can lead to secondary hyperparathyroidism. If coeliac disease remains untreated for long, tertiary hyperparathyroidism can also develop through autonomy of the parathyroid glands via chronic stimulation. Primary hyperparathyroidism

Agranulocytosis is a life-threatening disorder characterised by a greatly decreased number of circulating neutrophils below 500/μL. This article presents two cases of agranulocytosis in patients treated with pegylated interferon and ribavirin due to chronic hepatitis C. Interferon induced hyperthyroidism, which required the use of a tyreostatic. Anti-thyroid drugs (ATD) used to treat hyperthyroidism can cause agranulocytosis. The synergistic reaction of ATD and interferon on bone marrow cannot be excluded.

Stress is generally a natural phenomenon that affects behaviour, physiological processes, and neuroendocrine, neurochemical, neurological and immune responses. Many somatic and mental disorders are thought to result from chronic stress.

Type 1 diabetes is a chronic, incurable childhood disease. Chronically uncontrolled diabetes is associated with eye, kidney, nerve, heart and blood vessel damage and function impairment. The aim of this study was to evaluate the impact of various social and environmental factors, with a particular emphasis on education, on the level of metabolic control in diabetes.

In studies of obese adolescents in various countries, vitamin D deficiency has been correlated with greater weight andelevated BMI. However, there is insufficient data on the relation between vitamin D status and body fat indexes in adolescence. The aimof this study was to investigate the association of serum (25[OH]D) concentrations with body mass index of healthy Iranian subjects tounderstand whether specific data on the relation between vitamin D status and body mass index is common in all populations.

Angiogenesis plays an important role in tumour growth, progression and invasiveness. Vascular endothelial growth factor (VEGF) is a recognised angiogenesis-stimulating factor. Soluble VEGF receptors (sVEGFRs) have antiangiogenic properties. Recent studies have indicated that serum concentrations of these factors show a good correlation with the aggressiveness of these tumours in variousorgans. The aim of this study was to assess the usefulness of determining serum concentrations of VEGF and sVEGFR-2 in patients withadrenal incidentalomas